Role of Metallothionein in Transcriptional Regulation by Metal-Responsive Element-Binding Transcription Factor 1
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چکیده
منابع مشابه
Transcriptional Regulation of the Beta-Synuclein 59-Promoter Metal Response Element by Metal Transcription Factor-1
The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alphasynuclein belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that betasynuclein may be a natural regulator of alpha-synuclein. Therefore controlling beta-synuclein expression may control the accumulation of alpha-synuclein and ultimat...
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The progression of many human neurodegenerative disorders is associated with an accumulation of alpha-synuclein. Alpha-synuclein belongs to the homologous synuclein family, which includes beta-synuclein. It has been proposed that beta-synuclein may be a natural regulator of alpha-synuclein. Therefore controlling beta-synuclein expression may control the accumulation of alpha-synuclein and ultim...
متن کاملMolecular Mechanism of the Metallothionein Gene Expression Mediated by Metal-Responsive Transcription Factor 1
Metal-responsive transcription factor 1 (MTF-1) is essential for activating transcription of the metallothionein genes in response to multiple species of heavy metals by binding to the metal-responsive element (MRE) located in the upstream region of the genes. In contrast, MTF-1 binding to the MRE in vitro is induced only by zinc ions, suggesting that MTF-1 acts as a zinc sensor protein. Althou...
متن کاملMetallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1A
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role in zinc homeostasis, MT proteins can protect against metaland oxidant-induced cellular damage, and may participate in other fundamental physiologic and pathologic processes ...
متن کاملMetallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha.
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role in zinc homeostasis, MT proteins can protect against metal- and oxidant-induced cellular damage, and may participate in other fundamental physiologic and pathologic processe...
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ژورنال
عنوان ژورنال: BPB Reports
سال: 2020
ISSN: 2434-432X
DOI: 10.1248/bpbreports.3.1_22